Copine 3

CPNE3
Identifiers
Aliases	CPNE3, CPN3, PRO1071, copine 3
External IDs	OMIM: 604207 MGI: 1917818 HomoloGene: 20839 GeneCards: CPNE3
Gene location (Human) Chr. Chromosome 8 (human) Band 8q21.3 Start 86,514,435 bp End 86,561,498 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A3 Start 19,519,254 bp End 19,570,108 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone oral cavity bone marrow cells Achilles tendon gums caput epididymis germinal epithelium parietal pleura lactiferous duct seminal vesicula Top expressed in corneal stroma conjunctival fornix pyloric antrum pineal gland epithelium of stomach parotid gland Paneth cell left colon left lung lobe carotid body More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding receptor tyrosine kinase binding protein serine/threonine kinase activity calcium-dependent protein binding transporter activity calcium-dependent phospholipid binding RNA binding Cellular component extracellular exosome cytoplasm cytosol cell junction nucleus membrane focal adhesion plasma membrane nucleolus mitochondrion azurophil granule membrane Biological process ERBB2 signaling pathway glycerophospholipid biosynthetic process lipid metabolism cellular response to growth factor stimulus positive regulation of cell migration cellular response to calcium ion vesicle-mediated transport protein phosphorylation neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8895 70568 Ensembl ENSG00000085719 ENSMUSG00000028228 UniProt O75131 Q8BT60 RefSeq (mRNA) NM_003909 NM_027769 NM_001356481 RefSeq (protein) NP_003900 NP_082045 NP_001343410 Location (UCSC) Chr 8: 86.51 – 86.56 Mb Chr 4: 19.52 – 19.57 Mb PubMed search
Wikidata
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Copine 3 is a protein that in humans is encoded by the CPNE3 gene.

Function

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008].

Further reading

• Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF, Hoover R, Hayes RB, Hunter DJ, Chanock SJ (2008). "Multiple loci identified in a genome-wide association study of prostate cancer". Nat. Genet. 40 (3): 310–5. doi:10.1038/ng.91. PMID 18264096. S2CID 22978381.
• Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF, Hoover R, Hayes RB, Hunter DJ, Chanock SJ (2008). "Multiple loci identified in a genome-wide association study of prostate cancer". Nat. Genet. 40 (3): 310–5. doi:10.1038/ng.91. PMID 18264096. S2CID 22978381.
• Heinrich C, Keller C, Boulay A, Vecchi M, Bianchi M, Sack R, Lienhard S, Duss S, Hofsteenge J, Hynes NE (2010). "Copine-III interacts with ErbB2 and promotes tumor cell migration". Oncogene. 29 (11): 1598–610. doi:10.1038/onc.2009.456. PMID 20010870.
• Cohen OS, Mccoy SY, Middleton FA, Bialosuknia S, Zhang-James Y, Liu L, Tsuang MT, Faraone SV, Glatt SJ (2012). "Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia". Schizophr. Res. 142 (1–3): 188–99. doi:10.1016/j.schres.2012.09.015. PMC 3502694. PMID 23062752.
• Lin HC, Zhang FL, Geng Q, Yu T, Cui YQ, Liu XH, Li J, Yan MX, Liu L, He XH, Li JJ, Yao M (2013). "Quantitative proteomic analysis identifies CPNE3 as a novel metastasis-promoting gene in NSCLC". J. Proteome Res. 12 (7): 3423–33. doi:10.1021/pr400273z. PMID 23713811.
• Choi HY, Park N, Na JB, Ko ES, Park JY, Yoo JC (2016). "Direct binding of Copine3 with Jab1 activates downstream ErbB2 signaling and motility in SKBr3 breast cancer cells". Oncol. Rep. 35 (2): 1147–52. doi:10.3892/or.2015.4472. PMID 26719032.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.